Food and Environmental Allergies: Peanut

Food and Environmental allergies are Immunoglobulin E-mediated (IgE) responses to food and environmental allergens. Symptoms can range from allergic rhinitis to life-threatening anaphylaxis. Typical treatment of allergies involves avoidance of the allergen or management of the symptoms with medications such as anti-histamines. Furthermore, current immunotherapy treatments provide limited protection showing only limited protection against extremely small amounts of the allergen.

Eight types of food account for about 90% of all food-related allergic reactions. These foods are: Peanuts, Eggs, Milk, Tree Nuts, Fish, Shellfish, and Soy. Environmental allergens can be plant, animal, or insect based. Common environmental allergens include pollen, cats, dogs, and dust mites. COUR’s lead program in allergy is directed against the growing threat of peanut allergies in adults and children.

Peanut allergy affects approximately 3 million Americans. It is characterized by gastrointestinal, respiratory, skin, and systemic manifestations; in extreme cases anaphylaxis occurs and can rapidly become life-threatening. Current standard of care is focused on desensitization via OIT or maintaining a peanut-free diet.

COUR has developed CNP-201, a biodegradable nanoparticle encapsulating peanut protein.